Accelerating gene discovery
Accelerating gene discovery
Accelerating gene discovery
With the CRISPR system, researchers can diagnose, detect, and potentially treat a host of diseases within the body using gene editing.
CRISPR systems leverage a key feature of a bacterial defense system — Clustered Regularly Interspaced Short Palindromic Repeats — to target and edit specific stretches of genetic code, enabling scientists to tailor DNA within living cells and organisms much more easily than before.
MIT scientists are already using CRISPR systems to build sensitive tools for diagnosing human diseases and to accelerate the pace of research by quickly creating cell and animal models. In the future, CRISPR may make it possible to correct mutations in order to treat genetic causes of disease.
Using nature's tools to edit our genome. MIT scientists contribute to one of the century's most profound biological discoveries. Directed by Sarah Klein & Tom Mason of Redglass Pictures for the MIT School of Science. 2020.
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CRISPR Comes To COVID: A Pandemic Pivot And The Push For A Simple Coronavirus Test
MIT professor and Sherlock Biosciences co-founder Jim Collins predicts rapid progress on that front from a new technology — called “INSPECTR” — that would use synthetic biology methods to make a test on a simple paper strip. "In a matter of a small number of months," Collins says, the company "will be in a position to introduce an INSPECTR-based test for COVID-19."
MIT scientists explain the current state of COVID-19 testing, and how a CRISPR tool may help solve the supply problem.
CRISPR improves COVID-19 Testing
Q: What kind of COVID-19 test are you developing now? A: We are working on a nucleic acid-based test that does not require complex instrumentation, rapidly returns results (with a goal of under one hour), and can be performed at a point-of-care location without trained professionals. We hope to accomplish this using a combination of techniques. First, we are incorporating isothermal amplification technologies, which, unlike current PCR-based tests, do not require intricate heating and cooling to operate. We are combining this with our CRISPR-based diagnostics, allowing for sensitive detection and readout in a simple visual format, akin to a pregnancy test. We hope that this test will significantly lower the barrier for accurate diagnosis and provide another approach for COVID-19 surveillance.
Fighting lung cancer with CRISPR
New pathway for lung cancer treatment
Researchers in the Jacks lab used CRISPR to screen small cell lung cancer cell lines for genes that already have drugs targeting them, or that are likely to be druggable, in order to find therapeutic targets that can be tested more quickly and easily in a clinical setting.
‘Jumping genes’ could help CRISPR replace disease-causing DNA, study finds
DNA repairing "jumping genes"
The jumping-gene version of CRISPR is most likely to [be] best [over] the classic version when curing a genetic disease requires making a gene function normally by replacing its misspelled DNA “letters.” CRISPR tries to do that by cutting out the mutation (like Word snipping out fi from orthografi) and offering up the correct letters (phy).
Introducing genetic mutations with CRISPR offers a fast and accurate way to simulate disease.
Speeding up cancer research
Using the CRISPR gene-editing system, researchers have shown in mice that they can generate colon tumors that closely resemble human tumors. This advance should help scientists learn more about how the disease progresses and allow them to test new therapies.
Genome Editing with CRISPR – Cas9
The CRISPR-Cas9 method for genome editing is a powerful technology with many applications in biomedical research, including the potential to treat human genetic disease.
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CRISPR isn’t just for gene editing anymore
Scientists have unveiled a rapid, inexpensive, highly sensitive CRISPR-based diagnostic tool called SHERLOCK. Now, a strip of paper can indicate presence of pathogens, tumor DNA, or any genetic signature of interest with 100-fold greater sensitivity, the ability to detect multiple targets at once, and other new features that further enhance SHERLOCK's power.
After a decade, CRISPR gene editing is a 'revolution in progress.' What does the future hold?
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The CRISPR Pioneers
The new gene-editing technique that reveals cancer’s weaknesses
Meet one of the world's most groundbreaking scientists. He's 34.