Matthew Shoulders graduated summa cum laude from Virginia Tech in 2004 with a BS in Chemistry and a minor in Biochemistry, and then began doctoral work at the University of Wisconsin‐Madison under the direction of Professor Ronald Raines with the support of fellowships from the US Department of Homeland Security and the American Chemical Society Division of Medicinal Chemistry. After completing his PhD in 2009, he worked at the Scripps Research Institute in the lab of Professor Jeff Kelly as an American Cancer Society postdoctoral fellow. He joined the MIT Department of Chemistry in the summer of 2012 as an Assistant Professor.
Professor Shoulders studies protein homeostasis and folding, both of which are inextricably linked to disease states such as Alzheimer’s, diabetes, cystic fibrosis, and many types of cancer. Proteome repair achieved by targeting the cellular mechanisms that regulate protein folding could transform the therapeutic options for broad swaths of protein folding‐related disease, but much more must be learned about how proteins fold in the cell before such options can be developed. The Shoulders lab employs a multi‐disciplinary approach to (1) develop chemical and chemical biologic tools to manipulate and monitor cellular protein folding, (2) understand at the molecular level how the cell remodels itself to address challenges to protein homeostasis, (3) elucidate the pathophysiology of protein folding‐related diseases with poorly defined etiologies, and (4) target the biological processes discovered for the development of new small molecule probes, tools, and (ultimately) drugs.
Selected Awards and Honors
- National Science Foundation Faculty Early Career Development (CAREER) Award
IN THE NEWS
MIT NEWS OFFICE Biochemists discover mechanism that helps flu viruses evolve Sep 26, 2017
MIT NEWS OFFICE Twelve School of Science faculty appointed to career development professorships Sep 02, 2016
MIT NEWS OFFICE Matthew Shoulders receives NIH director's New Innovator Award Oct 16, 2015