Eliezer Calo focuses on the coordination of RNA metabolism using a combination of genetic, biochemical, and functional genomic approaches. The core of Calo’s research program is to understand how ribosome biogenesis is controlled by specific RNA binding proteins, particularly RNA helicases of the “DEAD box” family, and how disregulation of ribosome biogenesis contributes to various diseases, including cancer. He proposes initially to characterize the functions of specific genes of interest, including the DDX21 RNA helicase and the TCOF1 factor involved in RNA Pol I transcription and rRNA processing, using biochemical, molecular, and genome-wide approaches in mouse, Xenopus and Zebrafish models.
Calo is a familiar figure at MIT, having participated in MIT’s Summer Research Program (MSRP). After the 2006 completion of his undergraduate degree in chemistry from the University of Puerto Rico, he returned to MIT to pursue his PhD in cancer biology under the direction of Jacqueline Lees. In 2011, Calo began postdoctoral work at the Stanford University School of Medicine with Joanna Wysocka, where he changed fields from cancer biology to RNA biology. He returned to the Department of Biology in January 2017 as an assistant professor.
- Ph.D. 2011, MASSACHUSETTS INSTITUTE OF TECHNOLOGY (MIT)